Plasma kidney injury molecule-1 (p-KIM-1) levels and deterioration of kidney function over 16 years

Kidney injury molecule-1 (KIM-1): a novel kidney-specific injury molecule playing potential double-edged functions in kidney injury.

Kidney injury molecule-1 (KIM-1), a recently discovered transmembrane protein, is expressed in dedifferentiated proximal renal tubular epithelial cells in damaged regions. It may participate in the progress of renal injury or repair. Many studies have illustrated the different functions of KIM-1 in various renal diseases including protective functions in acute kidney injury and damaging functio...

Kidney Injury Molecule-1 (Kim-1) expression in murine polycystic kidney disease

Kidney Injury Molecule-1 (Kim-1) is a type 1 membrane protein maximally upregulated in proliferating and de-differentiated tubular cells after renal ischemia. Since epithelial dedifferentiation, proliferation and local ischemia may play a role in the pathophysiology of autosomal dominant polycystic kidney disease (ADPKD), we investigated Kim-1 expression in a mouse model of this disease. In the...

Kidney Injury Molecule -1 (Kim-1): A Tissue and Urinary Biomarker for Nephrotoxicant-Induced Renal Injury

Urinary kidney injury molecule-1 (Kim-1): a sensitive quantitative biomarker for early detection of kidney tubular injury

Sensitive and specific biomarkers are needed to detect early kidney injury. The objective of the present work was to develop a sensitive quantitative urinary test to identify renal injury in the rodent to facilitate early assessment of pathophysiological influence and drug toxicity. Two mouse monoclonal antibodies were made against the purified ectodomain of kidney injury molecule-1 (Kim-1) and...

Kidney injury molecule-1 and microalbuminuria levels in Zambian population: biomarkers of kidney injury

INTRODUCTION Kidney injury affects renal excretion of plasma analytes and metabolic waste products with grave pathologic consequences. Early detection, thus of kidney injury is essential for injury specific intervention that may avert permanent renal damage and delay progression of kidney injury. We aimed to evaluate Kidney Injury Molecule-1 (KIM-1) and Microalbuminuria (MAU), as biomarkers of ...